百问百答低危MDS治疗流程

35、低危MDS治疗流程（预后不良基因突变包括TP53、EZH2、ETV6、RUNX1及ASXL1等）

（摘自年ASH教育材料）

36、ELNriskstratificationbygenetics

Riskcategory*GeneticabnormalityFavorablet(8;21)(q22;q22.1);RUNX1-RUNX1T1inv(16)(p13.1q22)ort(16;16)(p13.1;q22);CBFB-MYH11MutatedNPM1withoutFLT3-ITDorwithFLT3-ITDlowBiallelicmutatedCEBPAIntermediateMutatedNPM1andFLT3-ITDhighWild-typeNPM1withoutFLT3-ITDorwithFLT3-ITDlow(withoutadverse-riskgeneticlesions)t(9;11)(p21.3;q23.3);MLLT3-KMT2ACytogeneticabnormalitiesnotclassifiedasfavorableoradverseAdverset(6;9)(p23;q34.1);DEK-NUPt(v;11q23.3);KMT2Arearrangedt(9;22)(q34.1;q11.2);BCR-ABL1inv(3)(q21.3q26.2)ort(3;3)(q21.3;q26.2);GATA2,MECOM(EVI1)?5ordel(5q);?7;?17/abn(17p)Complexkaryotype,monosomalkaryotypeWild-typeNPM1andFLT3-ITDhighMutatedRUNX1MutatedASXL1MutatedTP53

摘自“Blood.Jan26;(4):–.DiagnosisandmanagementofAMLinadults:ELNre







































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